Acclaim Trinity P1 Series

Acclaim Trinity P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications such as simultaneous separation of pharmaceutical drug substances ａnd their counterions. This new column, based on nanopolymer silica hybrid （NSH） technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, ａnd cation-exchange. As a result, its selectivity can be easily optimized by adjusting phase buffer concentration, pH, ａnd solvent content concurrently or independently. The NSH technology ensures distinctive spatial separation of the anion-exchange ａnd cation-exchange regions, which results in maximum flexibility in method development. The easy-to-optimize selectivity can be used to accelerate chromatographic separations ａnd increase productivity.

NSH Chromatographic Features

• Multiple retention mechanisms including reversed-phase, anion-exchange, ａnd cation-exchange
• Adjustable selectivity by phase ionic strength, electrolyte type, pH, ａnd organic solvent
• Ideal selectivity for simultaneous separation of basic, neutral, ａnd acidic analytes
• Separation of hydrophilic ionic ａnd ionizable analytes without ion-pairing reagents

Acclaim Trinity P1 Applications

• Active pharmaceutical ingredients （API） ａnd counterions （cations or anions）
• Screening of pharmaceutical counterions. Both UV ａnd evaporative light scattering （ELS） detectors, in series, are required for simultaneous determination of both drug substances ａnd counterions.
• Mixture of acidic ａnd basic drug substances ａnd respective counterions
• Drug substances of acidic, basic, ａnd neutral mixtures
• High throughput analysis following optimization of the selectivity ａnd resolution. The flow rate can then be increased, ａnd the analysis time shortened.

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